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I only had 32 lbs to lose to my ideal weight. I lost 26 lbs in the first 2 months so I quit taking them. Hubby felt that was enough and didnt want me on them very long. I have been off 2 months and have continued my good habits. I still have good control over my appetite etc. I have only lost 3 lbs in the last 2 months though and that is disappointing. But atleast I havent gained! I figure if I lose a pound a month I will be at my goal soon enough.
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Publisher: Humana Press
Number Of Pages: 483
Publication Date: 2006
ISBN / ASIN: 158829627X
Book Description:
This volume presents a critical appraisal of the neurological literature on neuromuscular disease from an evidence-based perspective. Writing in a readable, accessible style, the author considers, in detail, a broad range of the published literature relevant not only to questions of treatment, but also to issues of diagnosis and prognosis. Through a series of questions and answers concerning specific neuromuscular disorders, each chapter critiques the best available evidence to illustrate strengths and weaknesses of the data and make the reader aware of the quality of clinical research studies in general. Introductory chapters facilitate this learning process by elucidating the epidemiological and biostatistical issues pertinent to diagnosis, treatment, and prognosis. A broad range of disorders of the anterior horn cell, nerve roots, peripheral nerves, neuromuscular junction, and muscle are critically appraised and discussed.

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I’m often asked about why our district starts on a Friday instead of just waiting until Monday. The reason is, is that opening day glitches always occur and instead of having only a 16 hour turn-around time, we have more than 48 hours to work things out. And there are always things to work out. For instance I know that several bus drivers had not driven their routes before having to pick up children this morning. I know of at least one who got had no idea how to get to the child’s house before calling late last night to let them know the bus number and time of pick-up. Other issues include not enough books, not enough desks, issues with the cafeteria and basically all of the logistics.
As a teacher, the first day of school can be a very long and painful process, and we are very thankful to have a weekend the next day! No matter how much planning is done, it is never enough until the kids come. And there are usually surprises. In this case, my program was really surprised. At the end of last year, it looked like we were losing some kids as they were going to be attending their home schools. However one appealed and the other moved simply to remain in our school zone. In addition to the one new student I knew we were supposed to get (who didn’t show up) we got a new one who moved into our zone. So that zone next door had exactly one student show up, while we seemed swamped with 6! And there are more coming. I didn’t expect to feel this short this fast.
In other news, Georgia is once again observing a sales tax holiday this weekend. It started yesterday and is supposed to be for school clothes and supplies. And once again, teachers are getting a $100 gift card so that we can buy some needed supplies. I’m looking for some news on this, but apparently I’m going to be the one breaking it:
The Georgia Department of Education has received reports from teachers that some merchants are experiencing difficulties processing payments involving Teacher Gift Cards.
The Department has communicated these issues to Bank of America who has determined that there is an issue with the scan feature of the Teacher Gift Cards. Bank of America has assured the State that the problem will be corrected by tomorrow morning - Saturday August 2.
Bank of America recommends that if gift cards are used before tomorrow morning, merchants manually enter gift card information instead of using the scan feature.
The Georgia Department of Education regrets any inconvenience and greatly appreciates your patience as we work to resolve this issue as expediently as possible
Regards,

Scott D. Austensen, CFA
Deputy Superintendent, Finance Bus. Opns.
Georgia Department of Education
So there you have it. Teachers have to wait until tomorrow to use their gift cards because Bank of America has screwed them up. Why not just give us all $100 in cash? No glitches to worry about there! The reason for the gift cards is so that teachers who often dig into their own pockets for items won’t have to dig as deep. It’s along the same lines as the federal $250 deductions that teachers can take for buying stuff for our classroom s. It’s kind of an effort by the governor and the state legislature to buy more votes. In this case, teacher votes.
This year, we’re going to end up buying more than usual because the orders for supplies that we filed last February have not even been sent. So I can either buy my own stuff or ask parents to supply it for me. I don’t ask too much as the parents of my students are not rich by any stretch. They have their own needs and expenses, and I have learned to deal with what we have, mostly. But I think we’re going to need more bean bags for positioning and I’ll need more media storage space to back up computer files. The one thing I need most, but can’t really buy, is more time. I’ll just have to do better with the time that I have!
See you next week.

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After a rough couple of weeks, Barbara Wagner finally got some good news Monday.
Last month, she found out that her lung cancer, which had been in remission for about two years, had come back. After her oncologist prescribed a cancer drug that could slow the cancer growth and extend her life, Wagner was notified that the Oregon Health Plan wouldn’t cover the treatment, but that it would cover palliative, or comfort, care, including, if she chose, doctor-assisted suicide.
Then, on Monday morning, a representative of the pharmaceutical company called Wagner and told her it would provide the medicine for free. Wagner said she didn’t know whether to laugh or cry, so she did both.
“I am just so thrilled,” she said. “I am so relieved and so happy.”
Wagner had to rely on the charity of a drug company because the Oregon Health Plan wouldn’t cover her treatment.
“Treatment of advanced cancer that is meant to prolong life, or change the course of this disease, is not a covered benefit of the Oregon Health Plan,” said the unsigned letter Wagner received from LIPA, the Eugene company that administers the Oregon Health Plan in Lane County.
[...]
Coverage limitations
Numerous oncology studies have found that chemotherapy, used in a palliative setting, decreases pain, decreases time spent in the hospital and increases quality of life, Caton said.
When the Oregon Health Plan was established in 1994, it was expressly intended to ration health care. A prioritization list was drawn up, with diagnoses and ailments deemed most important — pregnancy, childbirth, preventive care for children — placed at the top of the list. At the bottom are procedures such as cosmetic surgery, which would not be covered.
“We can’t cover everything for everyone,” said Dr. Walter Shaffer, medical director of the state Division of Medical Assistance Programs, which administers the Oregon Health Plan.
“Taxpayer dollars are limited for publicly funded programs. We try to come up with polices that provide the most good for the most people.”
Most cancer treatments are high priority on the list, Shaffer said. “But there’s some desire on the part of the framers of this list to not cover treatments that are futile, or where the potential benefit to the patient is minimal in relation to the expense of providing the care.”
Dr. David Fryefield, medical director of the Willamette Valley Cancer Center in Eugene, said Oregon Health Plan policies haven’t kept up with advances in oncology.
“The prioritization list and the definitions and tests that are applied are 15 years old and not appropriate in today’s practice of oncology,” Fryefield said. “There are so many more targeted therapies that specifically target the cancer and have very few side effects.”
[...]
Dr. Som Saha, a Portland internist and chairman of the Health Services Commission, said the instances where chemotherapy is the only way to relieve someone’s symptoms are relatively rare.
“Chemotherapy is relatively costly, and relatively toxic,” he said. “And sometimes it’s the case where people will give chemotherapy with the intent of prolonging life when the extent of prolonged life is not substantial.”
Cancer drugs are notoriously expensive, often costing $3,000 to $6,000 a month, oncologists say. Tarceva, the drug that Wagner’s oncologist prescribed, costs $4,000 for a month’s supply.
Fryefield said chemotherapy today often falls in a gray area between comfort care and a cure. It can both extend life and maintain a patient’s quality of life, he said.
Many lack basic care
Consider the case of Randy Stroup, a 53-year-old Dexter resident who recently found out the Oregon Health Plan wouldn’t cover mitoxantrone, chemotherapy for prostate cancer.
Stroup’s oncologist, Dr. Andy Monticelli, said mitoxantrone, the first chemotherapy approved for prostate cancer, has been around about 10 years, and the benefit of using it for recurrent prostate cancer has been to shown to be “not huge, but measurable.”
“It would probably be of minimal benefit for a relatively short duration of probably several months,” he said.
But while the drug may not extend a patient’s life by very long, it does help make those last months more bearable by decreasing pain, he said.
Stroup said he wants what ever time he can get.
“My perspective is, if it works it works,” he said. “What is six months of life worth? To me it’s worth a lot.
“This is my life they’re playing with,” he said.
[...]
Wagner said she was devastated when she found out that the Oregon Health Plan wouldn’t cover Tarceva, the drug that her oncologist ordered when her lung cancer came back.
“I think it’s messed up,” Wagner said, bursting into tears.
She was particularly upset because the letter of denial said that doctor-assisted suicide would be covered.
“To say to someone, we’ll pay for you to die, but not pay for you to live, it’s cruel,” she said. “I get angry. Who do they think they are?”
[...]
Wagner, 64, lives in a low-income apartment in Springfield with her Dachshund, Chachi. She’s a divorced mother, grandmother and great-grandmother, retired from driving a school bus for the Springfield School District and working as a waitress at a Coburg truck stop.
She was a life-long smoker, quitting when she was diagnosed with non-small cell lung cancer about two years ago. Her oncologist, Dr. Jae Lee treated the cancer with chemotherapy and radiation and it went into remission, she said.
In early May, a CT scan revealed her cancer was back and Lee prescribed Tarceva, the brand name for erlotinib, a cancer drug in pill form taken once a day. Studies show the drug increased the median survival rate for patients with advanced non-small cell lung cancer from 4.7 months to 6.7 months. One-year survival for patients who took Tarceva was 31.2 percent, compared to 21.5 percent for patients who took a placebo.
Every patient, and every cancer, is different, and Lee said Wagner already has lived much longer than a typical lung cancer patient. Her cancer doesn’t grow rapidly, and he thinks Tarceva would help her.
Lee appealed to Genentech, the company that markets Tarceva in the United States, to cover Wagner’s medication. On Monday, Wagner got the call from Genentech. She was told they would cover the drug for a year, at which time she could re-apply. She expects to receive a visit today from FedEx.
“It’s fantastic,” she said. “I can’t wait to start the medication.

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MONTREAL, July 31 Aegera Therapeutics Inc. is pleased
to announce the dosing of the first patient in a fifth phase 1 and 2
clinical oncology study of AEG35156, a second generation antisense
therapeutic targeting XIAP, a key member of the Inhibitor of Apoptosis
protein family.
The study, made possible, in part, by funding from The Leukemia
Lymphoma Society, is entitled A Phase 1-2, Multicenter, Open-Label Study
of the X- Linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in
Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia, Small
Lymphocytic Lymphoma and Follicular Lymphoma. It is being conducted at the
Princess Margaret Hospital (PMH) located in Toronto, Ontario, and is led by
Principal Investigator Dr. Christine Chen, with co-Principal Investigators
Dr. Aaron Schimmer and Dr. Joe Brandwein, all from the PMHs Department of
Hematology and Oncology.
The primary objective of this study is to determine the recommended
dose of AEG35156 in patients with relapsed or refractory chronic
lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL) and follicular
lymphoma (FL), and to determine the safety profile and response rate to
AEG35156 in these patient populations.
Preliminary evidence of activity in lymphoma was observed in phase 1
studies with AEG35156, stated Dr. Jacques Jolivet, Aegeras VP Clinical.
This clinical trial will specifically study the role played by XIAP
knockdown in inducing antitumor activity in CLL, SLL and FL.Our clinical program around AEG35156 continues to expand and broaden
as we seek to move this therapeutic forward to approval, added Aegeras
President and Chief Executive Officer, Dr. Michael J. Berendt. By adding
these lymphoma indications to AEG35156s ongoing phase 1 and 2 studies in
leukemia (AML), pancreatic, breast, and non-small cell lung cancer, we
continue to seek to position AEG35156 as an important therapeutic option
that could address important unmet medical needs across a spectrum of
cancer indications. I must also thank, once again, The Leukemia Lymphoma
Society for their financial support of this study which is the first
funding granted for a clinical trial under their new Therapy Acceleration
Program.
The Leukemia Lymphoma Society Canada (LLSC) National Board Chairman,
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About AEG35156
Cancer cells acquire multiple mutations that disable their normal
response to apoptotic triggers. AEG35156, a second generation antisense
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without harming healthy cells. Aegeras published data with AEG35156, both
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as a novel drug target for the development of anti-cancer therapeutics.
About Aegera Therapeutics Inc.
Aegera Therapeutics is a clinical stage biotechnology company focused
on developing drugs that control apoptosis to address major unmet medical
needs. In addition to AEG35156, Aegera has three additional programs in
clinical development for the treatment of cancer and neuropathic pain.
Details of these programs can be found on Aegeras website at
http://www.aegera.com.
About The Leukemia Lymphoma Society
The Leukemia Lymphoma Society(R), headquartered in White Plains, NY,
with 68 chapters in the United States and Canada, is the worlds largest
voluntary health organization dedicated to funding blood cancer research
and providing education and patient services. The LLS mission: Cure
leukemia, lymphoma, Hodgkins disease and myeloma, and improve the quality
of life of patients and their families. Since its founding in 1949, LLS has
invested more than $600 million in research specifically targeting
leukemia, lymphoma and myeloma. Last year alone, LLS made 5.1 million
contacts with patients, caregivers and healthcare professionals.
For more information about blood cancer, visit http://www.LLS.org or call the
LLS Information Resource Center (IRC), a call center staffed by masters
level social workers, nurses and health educators who provide information,
support and resources to patients and their families and caregivers. IRC
information specialists are available at (800) 955-4572, Monday through
Friday, 9 a.m. to 6 p.m. ET.
For further information:
  Aegera Therapeutics Inc.
  Donald Olds, MSc, MBA
  Chief Operating Officer CFO
  (514) 288-5532 *295
  Email: donald.olds@aegera.com
SOURCE Aegera Therapeutics Inc.

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Publisher: Humana Press
Number Of Pages: 483
Publication Date: 2006
ISBN / ASIN: 158829627X
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